… of heart failure, and gene transfer therapies aimed at restoring … In failing human hearts,
PLN levels remain stable, whereas … positive outcomes in NYHA class II-III HF patients with …

… + cycling, Ca 2+ leak from the sarcoplasmic reticulum and … SERCA2a) gene transfer
successfully restored the Ca 2+ … TRPC3 overexpressing hearts were also more susceptible to …

… Ca 2+ is primarily stored within the sarcoplasmic reticulum (… using small molecule inhibitors
or gene therapy approaches. … stimulation and its downstream PKA first target LTCCs [4]. …

… Phase 1 and 2a human trials, in which the SERCA2a gene was … SUMOs covalently attach
to a target protein through a specific … gene therapy of sarcoplasmic reticulum Ca2+-ATPase in …

… aimed at preventing cardiac arrhythmias in cardiac disease. … with the pro-oxidant hormone
angiotensin II. After 3 weeks of … used for drug delivery places this type of therapy in the …

… AF can be treated with antiarrhythmic drug therapy, direct … + release channels (RyR) in
the sarcoplasmic reticulum (SR)… of its direct target, Acetyl-CoA carboxylase (ACC) (Figure 8). …

… common cardiac diseases, including myocardial infarction, arrhythmia, hypertrophy, heart
failure … treatments that to date, are able to target them and to revert the pathological phenotype. …

… In the heart, the sarcoplasmic reticulum (SR) is a Ca 2+ … In addition, we will also cover the
recent gene therapy of … of SERCA2a as a research target for heart failure treatment. Kho [55] …

… PKA and calcium/calmodulin-dependent protein kinase type II (… of a stable Ca2+ release
complex at the cardiac SR junctional … -2 gene delivery ameliorates heart failure progression in a …

… Here, we deliver sarcoplasmic reticulum Ca 2+ -ATPase 2a (… a promising cardiac repair
strategy for post-MI hearts that … Further, our results revealed improved ventricular electric stability …